A firefighter fights a blaze in Fontana, one day before the fire near the Getty Museum (AP Photo/Dan Steinberg)

The estimated 150-acre brush fire raging between the Getty Museum and Mount St. Mary's College has prompted the California Highway Patrol to close the 405 Freeway in both directions between Skirball Center Drive in the Sepulveda Pass and Sunset Blvd., according to CHP officials and updates via an online log. 405 north and southbound traffic is being diverted to the 10 Freeway and Valley Vista Rd. in Sherman Oaks, respectively.

The blaze, first reported at 12:51 a.m., had not damaged or put the museum or college in imminent danger, as of 2:51 a.m. With the conflagration moving in a southwesterly direction and no formal evacuation called, fire officials encouraged residents who could see flames to "calmly prepare to leave well in advance of the flames."

Over 300 firefighters and helicopters from various agencies reported to the scene.